Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Constitutive expression of interferons (IFNs) and activation of their signaling pathways have
pivotal roles in host responses to malignant cells in the tumor microenvironment. IFNs are …

Macrophages are major effector cells of the innate immune system, and appropriate
regulation of macrophage function requires the integration of multiple signalling inputs …

Therapeutic resistance to immune checkpoint blockers (ICBs) in melanoma patients is a
pressing issue, of which tumor loss of IFN-γ signaling genes is a major underlying …

Generally considered as a potent pro‑inflammatory signal, β‑galactosidelectin suppresses T
cell receptor activation, can both promote and inhibit integrin‑mediated adhesion and is …

Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules.
Their effector functions are tightly synchronized by the balance between the stimulatory and …

Complete activation of signal transducer and activator of transcription 1 (STAT1) requires
phosphorylation at both Y701 and a conserved PMS 727 P sequence. S727 …

Tumor biopsy is often not available or difficult to obtain in patients with solid tumors.
Investigation of the peripheral immune system allows for in-depth and dynamic profiling of …

Interferon-gamma (IFN-γ) has been identified as a crucial factor in determining the
responsiveness to immunotherapy. Produced primarily by natural killer (NK) and T cells, IFN …