Pathophysiology, clinical presentation, and treatment of psoriasis: a review

AW Armstrong, C Read - Jama, 2020 - jamanetwork.com
Importance Approximately 125 million people worldwide have psoriasis. Patients with
psoriasis experience substantial morbidity and increased rates of inflammatory arthritis …

Current concepts of psoriasis immunopathogenesis

M Vičić, M Kaštelan, I Brajac, V Sotošek… - International Journal of …, 2021 - mdpi.com
Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …

What causes hidradenitis suppurativa?—15 years after

CC Zouboulis, F Benhadou, AS Byrd… - Experimental …, 2020 - Wiley Online Library
The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis
published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International …

The inflammatory response in psoriasis: a comprehensive review

Y Deng, C Chang, Q Lu - Clinical reviews in allergy & immunology, 2016 - Springer
Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

The interleukin-23/interleukin-17 axis links adaptive and innate immunity in psoriasis

MP Schön, L Erpenbeck - Frontiers in immunology, 2018 - frontiersin.org
Research into the pathophysiology of psoriasis has shed light onto many fascinating
immunological interactions and underlying genetic constellations. Most prominent among …

[HTML][HTML] Tyrosine kinase 2 and Janus kinase‒signal transducer and activator of transcription signaling and inhibition in plaque psoriasis

JG Krueger, IB McInnes, A Blauvelt - Journal of the American Academy of …, 2022 - Elsevier
Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease.
The Janus kinase-signal transducer and activator of transcription pathway plays a major role …

Biologic treatments of psoriasis: an update for the clinician

ND Brownstone, J Hong, M Mosca… - … : Targets and Therapy, 2021 - Taylor & Francis
The advent of biologic agents within the past two decades has dramatically improved the
treatment of psoriasis and psoriatic arthritis. Given that there now exists 11 FDA approved …

Critical role of environmental factors in the pathogenesis of psoriasis

J Zeng, S Luo, Y Huang, Q Lu - The Journal of dermatology, 2017 - Wiley Online Library
Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and
non‐genetic factors, such as drugs, smoking, drinking, diet, infection and mental stress …

Role of AHR ligands in skin homeostasis and cutaneous inflammation

N Fernández-Gallego, F Sánchez-Madrid, D Cibrian - Cells, 2021 - mdpi.com
Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also
controls immune-mediated skin responses. The AHR modulates various physiological …

The role of IL-17 cytokines in psoriasis

M Mosca, J Hong, E Hadeler, M Hakimi… - ImmunoTargets and …, 2021 - Taylor & Francis
Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation.
The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically …