Colorectal cancer (CRC), and breast, ovarian, pancreatic and prostate cancers are generally
considered as low immune-reactive cancers that represent either limited infiltration of …

Prostate cancer is the most commonly diagnosed non-cutaneous cancers in North American
men. While androgen deprivation has remained as the cornerstone of prostate cancer …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …

Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype.
Here we investigated such a phenomenon in prostate cancer, in which tumours can escape …

Androgen receptor–positive prostate cancer (PCa) and estrogen receptor–positive luminal
breast cancer (BCa) are generally less responsive to immunotherapy compared with certain …

HOXB13, a homeodomain transcription factor, critically regulates androgen receptor (AR)
activities and androgen-dependent prostate cancer (PCa) growth. However, its functions in …

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of
multiple genes including MYC, and supraphysiological androgen is effective in some …

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …

Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal
differentiation that can arise at different anatomic sites but have strong histological and …