Heroin and its metabolites: relevance to heroin use disorder
Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …
Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions
Human immunodeficiency virus (HIV) remains a persistent public health concern throughout
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
the world. Substance use disorders (SUDs) are a common comorbidity that can worsen …
Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage
Osteoarthritis (OA) is characterized by cartilage damage, inflammation, and pain. Vascular
endothelial growth factor receptors (VEGFRs) have been associated with OA severity …
endothelial growth factor receptors (VEGFRs) have been associated with OA severity …
Circuit selectivity in drug versus natural reward seeking behaviors
Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …
and away from natural sources of reward (eg, social interaction, food, sex). The …
[HTML][HTML] Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: therapeutic potential of α-conotoxins
The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …
Regulation of cocaine-related behaviours by estrogen and progesterone
Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …
Behavioral and slice electrophysiological assessment of DREADD ligand, deschloroclozapine (DCZ) in rats
Abstract Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have
become a premier neuroscience research tool for enabling reversible manipulations of …
become a premier neuroscience research tool for enabling reversible manipulations of …
Perinatal morphine exposure leads to sex-dependent executive function deficits and microglial changes in mice
Children exposed prenatally to opioids are at an increased risk for behavioral problems and
executive function deficits. The prefrontal cortex (PFC) and amygdala (AMG) regulate …
executive function deficits. The prefrontal cortex (PFC) and amygdala (AMG) regulate …
Xylazine potentiates the lethal but not the rewarding effects of fentanyl in mice
P Acosta-Mares, V Violante-Soria, T Browne Jr… - Drug and Alcohol …, 2023 - Elsevier
Background Fentanyl is commonly laced with xylazine. People who use this combination
report heightened effects, but it also increases death risk. Although no medication has been …
report heightened effects, but it also increases death risk. Although no medication has been …
Cilia loss on distinct neuron populations differentially alters cocaine-induced locomotion and reward
T Everett, TW Ten Eyck, CH Wu… - Journal of …, 2024 - journals.sagepub.com
Background: Neuronal primary cilia are being recognized for their role in mediating
signaling associated with a variety of neurobehaviors, including responses to drugs of …
signaling associated with a variety of neurobehaviors, including responses to drugs of …