Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Macrophages represent a key component of the tumor microenvironment (TME) and are
largely associated with poor prognosis. Therapeutic targeting of macrophages has …

The extracellular matrix (ECM) is a vital component of the tumor microenvironment, which
interplays with stromal and tumor cells to stimulate the capacity of cancer cells to proliferate …

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults.
When ccRCC is localized to the kidney, surgical resection or ablation of the tumor is often …

Over the past few decades, with the rise of immunotherapies, tumor infiltrating immune cells
were increasingly investigated. Indeed, they may represent biomarkers for patient outcome …

Cancer continues to be a substantial health concern and a leading cause of death in the
United States and around the world. Therefore, it is important to continue to explore the …

Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop
therapeutic targets for mesothelioma. We identified two distinct macrophage populations in …

Bone tumors, including primary bone tumors and bone metastases, have been plagued by
poor prognosis for decades. Although most tumor tissue is removed, clinicians are still …

Objective: Pyridoxine 5′-phosphate oxidase (PNPO) is a key enzyme in the metabolism of
vitamin B6 and affects the tumorigenesis of ovarian and breast cancers. However, the roles …

Introduction Glutamine is characterized as the nutrient required in tumor cells. The study
based on glutamine metabolism aimed to develop a new predictive factor for pan-cancer …