MetaXcan: summary statistics based gene-level association method infers accurate PrediXcan results
To gain biological insight into the discoveries made by GWAS and meta-analysis studies,
effective integration of functional data generated by large-scale efforts such as the GTEx …
effective integration of functional data generated by large-scale efforts such as the GTEx …
Evaluation and application of summary statistic imputation to discover new height-associated loci
As most of the heritability of complex traits is attributed to common and low frequency
genetic variants, imputing them by combining genotyping chips and large sequenced …
genetic variants, imputing them by combining genotyping chips and large sequenced …
Multiple testing correction in linear mixed models
Background Multiple hypothesis testing is a major issue in genome-wide association studies
(GWAS), which often analyze millions of markers. The permutation test is considered to be …
(GWAS), which often analyze millions of markers. The permutation test is considered to be …
C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis
Elevated C-reactive protein (CRP) concentrations in the blood are associated with acute and
chronic infections and inflammation. Nevertheless, the functional role of increased CRP in …
chronic infections and inflammation. Nevertheless, the functional role of increased CRP in …
Prediction of Alzheimer's disease-associated genes by integration of GWAS summary data and expression data
Alzheimer's disease (AD) is the most common cause of dementia. It is the fifth leading cause
of death among elderly people. With high genetic heritability (79%), finding the disease's …
of death among elderly people. With high genetic heritability (79%), finding the disease's …
A powerful fine-mapping method for transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) have been recently applied to successfully
identify many novel genes associated with complex traits. While appealing, TWAS tend to …
identify many novel genes associated with complex traits. While appealing, TWAS tend to …
Trans‐Ethnic Fine‐Mapping of the Major Histocompatibility Complex Region Linked to Parkinson's Disease
Background Despite evidence for the role of human leukocyte antigen (HLA) in the genetic
predisposition to Parkinson's disease (PD), the complex haplotype structure and highly …
predisposition to Parkinson's disease (PD), the complex haplotype structure and highly …
Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a new method, SBayesRC, that integrates GWAS summary statistics with
functional genomic annotations to improve polygenic prediction of complex traits. Our …
functional genomic annotations to improve polygenic prediction of complex traits. Our …
Immunochip meta-analysis of inflammatory bowel disease identifies three novel loci and four novel associations in previously reported loci
Abstract Background and Aims Recent meta-analysis of genome-wide association studies
have identified over 241 inflammatory bowel disease susceptibility loci. However, the known …
have identified over 241 inflammatory bowel disease susceptibility loci. However, the known …
Incorporating functional annotations for fine-mapping causal variants in a Bayesian framework using summary statistics
W Chen, SK McDonnell, SN Thibodeau, LS Tillmans… - Genetics, 2016 - academic.oup.com
Functional annotations have been shown to improve both the discovery power and fine-
mapping accuracy in genome-wide association studies. However, the optimal strategy to …
mapping accuracy in genome-wide association studies. However, the optimal strategy to …