Emerging epigenetic insights into aging mechanisms and interventions
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …
still an evolving field with much to explore, it has rapidly gained significance by providing …
HIF‐1α‐induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation
X Lu, D Li, Z Lin, T Gao, Z Gong, Y Zhang, H Wang… - Aging …, 2024 - Wiley Online Library
The nucleus pulposus is in a hypoxic environment in the human body, and when
intervertebral disc degeneration (IVDD) occurs, the hypoxic environment is disrupted …
intervertebral disc degeneration (IVDD) occurs, the hypoxic environment is disrupted …
Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms
XW Liu, HW Xu, YY Yi, SB Zhang, SJ Chang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Age-related osteoporosis is characterized by a marked decrease in the number of
osteoblasts, which has been partly attributed to the senescence of cells of the osteoblastic …
osteoblasts, which has been partly attributed to the senescence of cells of the osteoblastic …