Surviving and adapting to stress: translational control and the integrated stress response
RC Wek, TG Anthony, KA Staschke - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …
response pathways that serve to restore proteostasis and enhance survival. A primary …
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
Free fatty acid induction of inflammation and cell death is an important feature of
nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the …
nonalcoholic steatohepatitis (NASH) and has been associated with disruption of the …
The integrated stress response in metabolic adaptation
HD Ryoo - Journal of Biological Chemistry, 2024 - ASBMB
The integrated stress response (ISR) refers to signaling pathways initiated by stress-
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …
activated eIF2α kinases. Distinct eIF2α kinases respond to different stress signals, including …
To die or not to die: death signaling in nonalcoholic fatty liver disease
Y Akazawa, K Nakao - Journal of gastroenterology, 2018 - Springer
Non-alcoholic fatty liver disease (NAFLD) is an emerging liver disease worldwide. In subset
of patients, NAFLD progresses to its advanced form, nonalcoholic steatohepatitis (NASH) …
of patients, NAFLD progresses to its advanced form, nonalcoholic steatohepatitis (NASH) …
mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in
translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway …
translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway …
A rare codon-based translational program of cell proliferation
Background The speed of translation elongation is primarily determined by the abundance
of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are …
of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are …
[HTML][HTML] Regulation of gene expression via translational buffering
Translation of an mRNA represents a critical step during the expression of protein-coding
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
genes. As mechanisms governing post-transcriptional regulation of gene expression are …
The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila
PERK is an endoplasmic reticulum (ER) transmembrane sensor that phosphorylates eIF2α
to initiate the Unfolded Protein Response (UPR). eIF2α phosphorylation promotes stress …
to initiate the Unfolded Protein Response (UPR). eIF2α phosphorylation promotes stress …
4E-BP is a target of the GCN2–ATF4 pathway during Drosophila development and aging
MJ Kang, D Vasudevan, K Kang, K Kim, JE Park… - Journal of Cell …, 2017 - rupress.org
Reduced amino acid availability attenuates mRNA translation in cells and helps to extend
lifespan in model organisms. The amino acid deprivation–activated kinase GCN2 mediates …
lifespan in model organisms. The amino acid deprivation–activated kinase GCN2 mediates …
Ribosome reinitiation directs gene-specific translation and regulates the integrated stress response
In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein
synthesis to conserve resources and facilitate preferential translation of transcripts that …
synthesis to conserve resources and facilitate preferential translation of transcripts that …