Estrogen receptor alpha (ER α) activity is associated with increased cancer cell proliferation.
Studies aiming to understand the impact of ER α on cancer‐associated phenotypes have …

Aminoacyl-tRNA synthetases (ARSs) catalyze the charging of specific amino acids onto
cognate tRNAs, an essential process for protein synthesis. Mutations in ARSs are frequently …

Abstract eIF2A was the first eukaryotic initiator tRNA carrier discovered but its exact function
has remained enigmatic. Uncharacteristic of translation initiation factors, eIF2A is reported to …

SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release,
immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential …

The IBTK gene encodes the IBtkα protein that is a substrate receptor of E3 ubiquitin ligase,
Cullin 3. We have previously reported the pro-tumorigenic activity of Ibtk in MYC-dependent …

Simple Summary The biological relevance of peptides that originate from non-canonical
translational initiation sites have been increasingly recognized over the years. Peptides …

In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein
synthesis while concomitantly promoting preferential translation of specific transcripts …

Multiple transcripts encode for the cell cycle inhibitor p21Cip1. These transcripts produce
identical proteins but differ in their 5'untranslated regions (UTRs). Although several stresses …

Objectives: There is a body of evidence that neurodegenerative disease entities are directly
correlated with the perturbations on the molecular level. Hence, the ER stress-mediated …

A peptide encoded within a 5′ untranslated region promotes p... : PAIN A peptide encoded
within a 5′ untranslated region promotes pain sensitization in mice : PAIN International …