Herpesviruses and the type III interferon system

Y Yin, HW Favoreel - Virologica Sinica, 2021 - Springer
Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together
with type I IFNs (eg IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune …

Toll‐like receptors as novel therapeutic targets for herpes simplex virus infection

R Jahanban‐Esfahlan, K Seidi… - Reviews in Medical …, 2019 - Wiley Online Library
Seropositivity for HSV reaches more than 70% within the world population, and yet no
approved vaccine exists. While HSV1 is responsible for keratitis, encephalitis, and labialis …

[HTML][HTML] Poly (dA: dT) suppresses HSV-2 infection of human cervical epithelial cells through RIG-I activation

DD Shao, FZ Meng, Y Liu, XQ Xu, X Wang… - Frontiers in …, 2021 - frontiersin.org
Epithelial cells of the female reproductive tract (FRT) participate in the initial innate immunity
against viral infections. Poly (dA: dT) is a synthetic analog of B form double-stranded (ds) …

[HTML][HTML] Exosomes transport anti-human immunodeficiency virus factors from human cervical epithelial cells to macrophages

XQ Xu, B Zhang, L Guo, Y Liu, FZ Meng… - Journal of Innate …, 2021 - karger.com
The female reproductive tract (FRT) is a major site of HIV sexual transmission. As the
outermost layer of cells in the FRT, the human cervical epithelial cells (HCEs) have direct …

[HTML][HTML] Human cervical epithelial cells release antiviral factors and inhibit HIV replication in macrophages

XQ Xu, L Guo, X Wang, Y Liu, H Liu, RH Zhou… - Journal of innate …, 2018 - karger.com
The female reproductive tract is a major site of HIV sexual transmission. We here examined
whether human cervical epithelial cells (HCEs) can be immunologically activated and …

IFN-λs inhibit Hantaan virus infection through the JAK-STAT pathway and expression of Mx2 protein

N Li, F Luo, Q Chen, N Zhu, H Wang, L Xie, H Xiong… - Genes & …, 2019 - nature.com
Hantaan virus (HTNV), member of the newly defined Hantaviridae family, within the order
Bunyavirales, can cause a hemorrhagic fever with renal syndrome with high fatality rates in …

The Us2 gene product of herpes simplex virus 2 modulates NF-κB activation by targeting TAK1

X Lu, C Huang, Y Zhang, Y Lin, X Wang, Q Li, S Liu… - Scientific Reports, 2017 - nature.com
HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2
infection triggers cytokine and chemokine production. However, little is known about which …

Functional Roles of Pattern Recognition Receptors That Recognize Virus Nucleic Acids in Human Adipose‐Derived Mesenchymal Stem Cells

L Yu, Y Xu, F Wang, C Yang, G Liu… - BioMed Research …, 2016 - Wiley Online Library
Human adipose‐derived mesenchymal stem cells (hAD‐MSCs) are mesenchymal stem
cells with the capability to modulate immune responses. Evidence showing that hAD‐MSCs …

HSV-2 Infection Enhances Zika Virus Infection of Primary Genital Epithelial Cells Independently of the Known Zika Virus Receptor AXL

GG Gornalusse, M Zhang, R Wang… - Frontiers in …, 2022 - frontiersin.org
Zika virus (ZIKV) is transmitted to people by bite of an infected mosquito and by sexual
contact. ZIKV infects primary genital epithelial cells, the same cells targeted by herpes …

[HTML][HTML] Interleukin 21 treatment in a murine model as a novel potential cytokine immunotherapy for colon cancer

C Chen, X Liu, Y Ren - Advances in Clinical and Experimental …, 2018 - advances.umw.edu.pl
Background. Interleukin 21 (IL-21), which belongs to the common γ-chain (γc) family, is a
novel tumor suppressor that has been shown to affect T-cell proliferation, survival and …