Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

Growing human organs in animals sounds like something from the realm of science fiction,
but it may one day become a reality through a technique known as interspecies blastocyst …

Human embryonic stem cells (hESCs) can be captured in a primed state in which they
resemble the postimplantation epiblast, or in a naive state where they resemble the …

Naive human induced pluripotent stem cells (iPSCs) can be generated by reprogramming
somatic cells with Sendai virus (SeV) vectors. However, only dermal fibroblasts have been …

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the blastocyst.
ESCs have two distinctive properties: ability to proliferate indefinitely, a feature referred as …

Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients
whose β-cell functions have been abolished. However, the lack of donor organs has been …

Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …

Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental
tissues with multidirectional differentiation potential and excellent self-renewing ability …

Highlights•Human dosage compensation mechanisms cannot be adequately modeled in
mice.•Naive human pluripotent stem cells (hPSCs) model X-chromosome dampening.•Naive …

Recent research revealed a rejuvenation event during early development of mice. Here, by
examining epigenetic age dynamics of human embryogenesis, we tested whether a similar …