During early mammalian embryonic development, fertilized one-cell embryos develop into
pre-implantation blastocysts and subsequently establish three germ layers through …

XIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X
chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X …

The past decade has seen significant interest in the isolation of pluripotent stem cells
corresponding to various stages of mammalian embryonic development. Two distinct and …

The totipotent embryo initiates transcription during zygotic or embryonic genome activation
(EGA, ZGA). ZGA occurs at the 8-cell stage in humans and its failure leads to developmental …

Lima1 is an extensively studied prognostic marker of malignancy and is also considered to
be a tumour suppressor, but its role in a developmental context of non-transformed cells is …

After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit
very low ability to make interspecies chimeras. Whether this is because they are inherently …

Human pluripotent stem cells (hPSCs) regularly and irreversibly show the erosion of X
chromosome inactivation (XCI) by long non-coding RNA (lncRNA) XIST silencing, causing …

The shortage of human organs for transplantation is a devastating medical problem. One
way to expand organ supply is to derive functional organs from patient-specific stem cells …

Hypoxia-inducible factor 1α (HIF-1α) plays pivotal roles in maintaining pluripotency, and the
developmental potential of pluripotent stem cells (PSCs). However, the mechanisms …

Human periimplantation development requires the transformation of the naive pluripotent
epiblast into a polarized epithelium. Lumenogenesis plays a critical role in this process, as …