The problem of reconstructing nonlinear and complex dynamical systems from measured
data or time series is central to many scientific disciplines including physical, biological …

Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

INTRODUCTION Although recent advances in DNA synthesis and sequencing technologies
have made practical the writing and readout of arbitrary data in the form of synthetic DNA …

Cybergenetics is a novel field of research aiming at remotely pilot cellular processes in real-
time with to leverage the biotechnological potential of synthetic biology. Yet, the control of …

In spite of the recent interest and advances in linear controllability of complex networks,
controlling nonlinear network dynamics remains an outstanding problem. Here we develop …

Synthetic biology is the application of engineering principles to the fundamental components
of biology, with the aim of creating systems with novel functionalities that can be used for …

Remarkable progress in bioengineering over the past two decades has enabled the
formulation of fundamental design principles for a variety of medical and non-medical …

Programmable CRISPR-Cas systems have augmented our ability to produce precise
genome manipulations. Here we demonstrate and characterize the ability of CRISPR-Cas …

Highlights•Cellular computation will enable applications envisioned by synthetic
biologists.•Digital cellular circuits can perform increasingly complex logic functions.•Recent …