The murine Six gene family, homologous to Drosophila sine oculis (so) which encodes a
homeodomain transcription factor, is composed of six members (Six1-6). Among the six …

The Notch gene family encodes large transmembrane receptors that are components of an
evolutionarily conserved intercellular signaling mechanism. To assess the in vivo role of the …

Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive
interactions between the branching ureteric buds and the metanephric mesenchyme lead to …

The mammalian Hox complex is divided into four linkage groups containing 13 sets of
paralogous genes. These paralogous genes have retained functional redundancy during …

The outgrowth of the ureteric bud from the posterior nephric duct epithelium and the
subsequent invasion of the bud into the metanephric mesenchyme initiate the process of …

This educational review will highlight the historical and contemporary references that
establish a basic understanding of measurements of kidney function in the neonate and its …

Six genes are widely expressed during vertebrate embryogenesis, suggesting that they are
implicated in diverse differentiation processes. To determine the functions of the Six1 gene …

Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with
deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development. To …

The uterus is an essential organ for reproduction in mammals. Despite the importance of the
uterus for the fertility and health of women and their offspring, relatively little is known about …

Integrin-linked kinase (ILK) is a serine/threonine protein kinase which interacts with the
cytoplasmic domains of β1 and β3 integrins. ILK structure and its localization at the focal …