The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Insufficient intracellular anabolism is a crucial factor involved in many pathological
processes in the body,. The anabolism of intracellular substances requires the consumption …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Macrophages are one of the first innate immune cells to reach the site of infection or injury.
Diverse functions from the uptake of pathogen or antigen, its killing, and presentation, the …

Vascular smooth muscle cells (VSMCs) play important roles not only in the physiological
functions of the blood vessels, such as vasoconstriction, vasodilatation and extracellular …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …

Over the past century, solid organ transplantation has been improved both at a surgical and
postoperative level. However, despite the improvement in efficiency, safety, and survival, we …

Tumors employ strategies to escape immune control. The principle aim of most cancer
immunotherapies is to restore effective immune surveillance. Among the different processes …

Coronavirus disease 2019 (COVID-19) represents a major public health crisis that has
caused the death of nearly six million people worldwide. Emerging data have identified a …