The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Targeting immunometabolism against acute lung injury

L Ning, Z Shishi, W Bo, L Huiqing - Clinical Immunology, 2023 - Elsevier
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

A systematic review and meta-analysis of the association between the neutrophil, lymphocyte, and platelet count, neutrophil-to-lymphocyte ratio, and platelet-to …

A Zinellu, AA Mangoni - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Background and aims Severe manifestations of coronavirus disease 2019 (COVID-19) are
associated with alterations in blood cells that regulate immunity, inflammation, and …

Neutrophil/lymphocyte ratio (NLR) and lymphocyte/monocyte ratio (LMR)–risk of death inflammatory biomarkers in patients with COVID-19

V Dymicka-Piekarska, J Dorf, A Milewska… - Journal of …, 2023 - Taylor & Francis
Aim The aim of our retrospective study was search for new prognostic parameters, which
can help quickly and cheaply identify patients with risk for severe course of SARS-CoV-2 …

Upregulation of PD‐1 Expression and High sPD‐L1 Levels Associated with COVID‐19 Severity

DR Beserra, RW Alberca, ACCC Branco… - Journal of …, 2022 - Wiley Online Library
COVID‐19 has several mechanisms that can lead to lymphocyte depletion/exhaustion. The
checkpoint inhibitor molecule programmed death protein 1 (PD‐1) and its programmed …

Blood transcriptome responses in patients correlate with severity of COVID-19 disease

Y Wang, K Schughart, TM Pelaia, T Chew… - Frontiers in …, 2023 - frontiersin.org
Background Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Infected individuals …

Cellular immune states in SARS-CoV-2-induced disease

K Mortezaee, J Majidpoor - Frontiers in immunology, 2022 - frontiersin.org
The general immune state plays important roles against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. Cells of the immune system are encountering rapid …

[HTML][HTML] Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention

DR Sweet, ML Freeman, DA Zidar - Pathogens and Immunity, 2023 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) has had profound effects on the health of
individuals and on healthcare systems worldwide. While healthcare workers on the …

Host response changes and their association with mortality in COVID-19 patients with lymphopenia

EHA Michels, B Appelman, J de Brabander… - American journal of …, 2024 - atsjournals.org
Rationale: Lymphopenia in coronavirus disease (COVID-19) is associated with increased
mortality. Objectives: To explore the association between lymphopenia, host response …

Utility of monocyte expression of HLA-DR versus T lymphocyte frequency in the assessment of COVID-19 outcome

R Hammad, HG Kotb, GAR Eldesoky… - … Journal of General …, 2022 - Taylor & Francis
Background Dysregulated immunity is a hallmark of SARS-CoV-2 infection. Immune
suppression is indicated by low monocyte expression of human leukocyte antigen D-related …