Overview and update on methods for cargo loading into extracellular vesicles

Y Han, TW Jones, S Dutta, Y Zhu, X Wang… - Processes, 2021 - mdpi.com
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …

Targeting the blood-brain barrier for the delivery of stroke therapies

A D'Souza, KM Dave, RA Stetler… - Advanced drug delivery …, 2021 - Elsevier
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy

SE Ahmadi, M Soleymani, F Shahriyary… - Cancer Gene …, 2023 - nature.com
Gene editing-based therapeutic strategies grant the power to override cell machinery and
alter faulty genes contributing to disease development like cancer. Nowadays, the principal …

Red blood cell extracellular vesicle-based drug delivery: challenges and opportunities

W Chiangjong, P Netsirisawan, S Hongeng… - Frontiers in …, 2021 - frontiersin.org
Recently, red blood cell-derived extracellular vesicles (RBCEVs) have attracted attention for
clinical applications because of their safety and biocompatibility. RBCEVs can escape …

Exosomes deliver lncRNA DARS-AS1 siRNA to inhibit chronic unpredictable mild stress-induced TNBC metastasis

X Liu, G Zhang, T Yu, J He, J Liu, X Chai, G Zhao, D Yin… - Cancer letters, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is a rapidly recurring and highly metastatic
malignancy with high heterogeneity and chemoradiotherapy resistance. Chronic …

Viral Vectors, Exosomes, and Vexosomes: Potential armamentarium for delivering CRISPR/Cas to cancer cells

M Farzanehpour, A Miri, AG Alvanegh… - Biochemical …, 2023 - Elsevier
The underlying cause of cancer is genetic disruption, so gene editing technologies,
particularly CRISPR/Cas systems can be used to go against cancer. The field of gene …

Development of new strategies using extracellular vesicles loaded with exogenous nucleic acid

NS Orefice - Pharmaceutics, 2020 - mdpi.com
Gene therapy is a therapeutic strategy of delivering foreign genetic material (encoding for an
important protein) into a patient's target cell to replace a defective gene. Nucleic acids are …

Extending applications of AFM to fluidic AFM in single living cell studies

Y Qiu, CC Chien, B Maroulis, J Bei… - Journal of cellular …, 2022 - Wiley Online Library
In this article, a review of a series of applications of atomic force microscopy (AFM) and
fluidic Atomic Force Microscopy (fluidic AFM, hereafter fluidFM) in single‐cell studies is …

Extracellular vesicles and their current role in cancer immunotherapy

C Giacobino, M Canta, C Fornaguera, S Borrós… - Cancers, 2021 - mdpi.com
Simple Summary In recent years, immunotherapy has shown great advancement, becoming
a powerful tool to combat cancer. In this context, the use of biologically derived vesicles has …

Extracellular vesicles: a novel opportunity for precision medicine in respiratory diseases

JM Carnino, Z Hao Kwok, Y Jin - Frontiers in medicine, 2021 - frontiersin.org
Extracellular vesicles are membrane-bound nanoparticles secreted by cells which play a
well-known role in cell to cell communication. The most update to date nomenclature …