Alzheimer's disease (AD) is currently constrained by limited clinical treatment options. The
initial pathophysiological event, which can be traced back to decades before the clinical …

ApoE plays an important and well established role in dyslipidemia, vascular disease, and
dementia. Recent evidence from large general population studies now also suggests that …

Background: In recent years, microRNAs (miRNAs) have emerged as key players in the
pathophysiology of multiple diseases including Alzheimer's disease (AD). Messenger RNA …

Alzheimer's disease (AD) is the most common cause of neurodegenerative impairment in
elderly people. Clinical characteristics include short-term memory loss, confusion …

Importance Blood levels of phosphorylated tau 217 (p-tau217) as measured by
commercially available immunoassays are an emerging tool to assess Alzheimer's disease …

The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with low tau
pathology and slowdown of cognitive decline despite the causal PSEN1 mutation and high …

AlzheimerLs disease (AD) is the most common cause of neurodegenerative impairment in
elderly people. Clinical characteristics include short-term memory loss, confusion …

The ability of glia to tightly regulate neuronal health and homeostasis in the CNS is
conserved across species. Yet, despite the ability to degrade protein aggregates, glia are …

El Alzheimer es una enfermedad que afecta la memoria y la función cerebral, ha sido un
enigma durante mucho tiempo. Los científicos llevan años tratando de entender sus causas …