Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory
to inhibition by agents recently introduced. Most important among these are the class B …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze and
inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute> 50 …

New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the
penicillin, cephalosporin and 'last resort'carbapenems, and thus confers bacterial resistance …

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …

Resistance to β-lactam antibiotics in Gram-negatives producing metallo-β-lactamases
(MBLs) represents a major medical threat and there is an extremely urgent need to develop …

Drug-resistant pathogens pose a global challenge to public health as they cause diseases
that are extremely difficult to cure. Metallo-β-lactamases (MBLs) are a diverse set of zinc …