Background Inherited cardiomyopathies present with broad variation of phenotype. Data are
limited regarding genetic screening strategies and outcomes associated with predicted …

Leveraging genetics insights to promote drug repurposing has become a promising and
active strategy in pharmacology. Indeed, among the 50 drugs approved by FDA in 2021, two …

The human genome contains hundreds of thousands of regions harboring copy-number
variants (CNV). However, the phenotypic effects of most such polymorphisms are unknown …

Genetic associations with macroscopic brain structure can provide insights into brain
function and disease. However, specific associations with measures of local brain folding …

White matter hyperintensities (WMH) are among the most common radiological
abnormalities in the ageing population and an established risk factor for stroke and …

Background & Aims Lean patients with non-alcoholic fatty liver disease (NAFLD) represent
10–20% of the affected population and may have heterogeneous drivers of disease. We …

Despite thousands of common genetic loci of major depression disorders (MDD) have been
identified by GWAS to date, a large proportion of genetic variation predisposing to MDD …

Alcohol consumption is a heritable behavior seriously endangers human health. However,
genetic studies on alcohol consumption primarily focuses on common variants, while …

The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs)
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …

PURPOSE Prostate cancer (PCa) is highly heritable. No validated PCa risk model currently
exists. We therefore sought to develop a genetic risk model that can provide personalized …