Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Since the beginning of time people explored and developed new technologies to make their
activities of daily living less labour intense, more efficient and, consequently, more …

Background: The cancer burden in the United States of America (USA) has decreased
gradually. However, China is experiencing a transition in its cancer profiles, with greater …

Objectives To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study
2019 (GBD 2019) to estimate mortality and disability trends for the population aged≥ 70 …

Background Low bone mineral density (LBMD), including osteoporosis and low bone mass,
has becoming a serious public health concern. We aimed to estimate the disease burden of …

Objective To evaluate the global burden of musculoskeletal (MSK) disorders, as well as the
five common conditions, and their relevant risk factors from 1990 to 2019. Design Data from …

Macroautophagy decreases with age, and this change is considered a hallmark of the aging
process. It remains unknown whether mitophagy, the essential selective autophagic …

By 2050, it is estimated that about a fifth of the general population will be aged 65 years and
older. 1 Social isolation and loneliness among young (18–40 years), middle-aged (41–64) …

Background Peptic ulcer disease (PUD) affects four million people worldwide annually and
has an estimated lifetime prevalence of 5− 10% in the general population. Worldwide, there …

Aging is the progressive decline or loss of function at the cellular, tissue, and organismal
levels that ultimately leads to death. A number of external and internal factors, including diet …