Analysis of SARS-CoV-2 mutations associated with resistance to therapeutic monoclonal antibodies that emerge after treatment.

D Focosi, S McConnell, DJ Sullivan… - Drug Resistance Updates, 2023 - Elsevier
The mutation rate of the Omicron sublineage has led to baseline resistance against all
previously authorized anti-Spike monoclonal antibodies (mAbs). Nevertheless, in case more …

[HTML][HTML] SARS-CoV-2 variants resistant to monoclonal antibodies in immunocompromised patients is a public health concern

A Casadevall, D Focosi - The Journal of clinical …, 2023 - Am Soc Clin Investig
COVID-19 in immunocompromised hosts has emerged as a difficult therapeutic
management problem. Immunocompromised hosts mount weak responses to SARS-CoV-2 …

[HTML][HTML] Have Diagnostics, Therapies, and Vaccines Made the Difference in the Pandemic Evolution of COVID-19 in Comparison with “Spanish Flu”?

F Lista, MS Peragallo, R Biselli, R De Santis, S Mariotti… - Pathogens, 2023 - mdpi.com
In 1918 many countries, but not Spain, were fighting World War I. Spanish press could report
about the diffusion and severity of a new infection without censorship for the first-time, so that …

SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency

Y Li, MC Choudhary, J Regan, J Boucau… - Science Translational …, 2024 - science.org
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the …

VEGF-A plasma levels are associated with impaired DLCO and radiological sequelae in long COVID patients

A Philippe, S Günther, J Rancic, P Cavagna, B Renaud… - Angiogenesis, 2024 - Springer
Background Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is
characterized by persistent clinical symptoms following COVID-19. Objective To correlate …

SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs

S Iketani, DD Ho - Cell Chemical Biology, 2024 - cell.com
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific
response has been rapid and effective, with many therapeutic monoclonal antibodies and …

[HTML][HTML] SARS-CoV-2 viral clearance and evolution varies by extent of immunodeficiency

Y Li, MC Choudhary, J Regan, J Boucau, A Nathan… - medRxiv, 2023 - ncbi.nlm.nih.gov
Despite vaccination and antiviral therapies, immunocompromised individuals are at risk for
prolonged SARS-CoV-2 infection, but the immune defects that predispose to persistent …

SARS-CoV-2 genomics and impact on clinical care for COVID-19

R Lorenzo-Redondo… - Journal of …, 2023 - academic.oup.com
The emergence and worldwide spread of SARS-CoV-2 during the COVID-19 pandemic
necessitated the adaptation and rapid deployment of viral WGS and analysis techniques that …

[HTML][HTML] Effect of molnupiravir on SARS-CoV-2 evolution in immunocompromised patients: a retrospective observational study

NM Fountain-Jones, R Vanhaeften, J Williamson… - The Lancet …, 2024 - thelancet.com
Summary Introduction Continued SARS-CoV-2 infection among immunocompromised
individuals is likely to play a role in generating genomic diversity and the emergence of …

[HTML][HTML] Sotrovimab: A Review of Its Efficacy against SARS-CoV-2 Variants

D Focosi, A Casadevall, M Franchini, F Maggi - Viruses, 2024 - mdpi.com
Among the anti-Spike monoclonal antibodies (mAbs), the S-309 derivative sotrovimab was
the most successful in having the longest temporal window of clinical use, showing a high …