[HTML][HTML] Oxidative stress in the eye and its role in the pathophysiology of ocular diseases

EW Böhm, F Buonfiglio, AM Voigt, P Bachmann, T Safi… - Redox Biology, 2023 - Elsevier
Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Oxidative stress and antioxidants in cataract development

B Lee, NA Afshari, PX Shaw - Current Opinion in Ophthalmology, 2024 - journals.lww.com
Oxidative stress is a significant contributor to cataract development, underscoring the
importance of antioxidants in diagnosis and treatment. Notably, GSH depletion, SOD …

Potential New Target for Dry Eye Disease—Oxidative Stress

J Bu, Y Liu, R Zhang, S Lin, J Zhuang, L Sun, L Zhang… - Antioxidants, 2024 - mdpi.com
Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It is
characterized by loss of tear film homeostasis and accompanied by ocular symptoms that …

Novel treatments for dry eye syndrome

E Roucaute, M Huertas-Bello, AL Sabater - Current Opinion in …, 2024 - Elsevier
Dry eye syndrome (DES) is a prevalent and multifactorial disease that leads to a self-
perpetuating cycle of inflammation and damage to the ocular surface. This results in …

Lactobacillus fermentum HY7302 Improves Dry Eye Symptoms in a Mouse Model of Benzalkonium Chloride-Induced Eye Dysfunction and Human Conjunctiva …

K Lee, JW Jeong, JJ Shim, HS Hong, JY Kim… - International Journal of …, 2023 - mdpi.com
(1) We investigated the effects of the Lactobacillus fermentum HY7302 (HY7302) in a mouse
model of benzalkonium chloride (BAC)-induced dry eye, and the possibility of using HY7302 …

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

L Zeng, K Yang, G Yu, W Hao, X Zhu, A Ge… - Cell Death & …, 2024 - nature.com
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …

Silibinin alleviates DNA damage, mitochondrial dysfunction, and apoptosis caused by oxidative stress in human retinal pigment epithelial cells

YH Choi - Molecular & Cellular Toxicology, 2024 - Springer
Background Silibinin, a flavonolignan, is known to have a variety of pharmacological
activities, including antioxidant activity, but its antioxidant mechanism in the eye is unclear …

[HTML][HTML] Lid scrubbing with a gel combining natural extracts for dry eye treatment

B Diaz-Vega, C Rodriguez-Fabuel… - International Journal …, 2023 - ncbi.nlm.nih.gov
AIM To evaluate the effect of lid scrubbing using a gel combining different natural extracts on
ocular signs and symptoms of dry eye patients. METHODS A retrospective study was …

[HTML][HTML] Myclobutanil induces cardiotoxicity in developing zebrafish larvae by initiating oxidative stress and apoptosis: The protective role of curcumin

C Liu, F Yang, J Wang, R Zhu, J Zhu… - … and Environmental Safety, 2024 - Elsevier
Myclobutanil (MYC) is a common triazole fungicide widely applied in agriculture. MYC
extensively exists in the natural environment and can be detected in organisms. However …

Bioinformatics analysis of signature genes related to cell death in keratoconus

J Liu, J Gao, S Xing, Y Yan, X Yan, Y Jing, X Li - Scientific Reports, 2024 - nature.com
Keratoconus is corneal disease in which the progression of conical dilation of cornea leads
to reduced visual acuity and even corneal perforation. However, the etiology mechanism of …