The bone extracellular matrix in bone formation and regeneration

X Lin, S Patil, YG Gao, A Qian - Frontiers in pharmacology, 2020 - frontiersin.org
Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent
due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio …

Vitamin K–sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity

P Mladěnka, K Macáková, L Kujovská Krčmová… - Nutrition …, 2022 - academic.oup.com
Vitamin K is traditionally connected with blood coagulation, since it is needed for the
posttranslational modification of 7 proteins involved in this cascade. However, it is also …

Vitamin K: double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease

M Halder, P Petsophonsakul, AC Akbulut… - International journal of …, 2019 - mdpi.com
Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K
can be present in various isoforms, distinguishable by two main structures, namely …

Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences

RA Youness, A Dawoud, O ElTahtawy, MA Farag - Nutrition & Metabolism, 2022 - Springer
Age and Gender are vital determinants for the micronutrient demands of normal indviduals.
Among these micronutrients are vitamins that are required in small amounts for optimum …

Vitamin K as a diet supplement with impact in human health: current evidence in age-related diseases

DC Simes, CSB Viegas, N Araújo, C Marreiros - Nutrients, 2020 - mdpi.com
Vitamin K health benefits have been recently widely shown to extend beyond blood
homeostasis and implicated in chronic low-grade inflammatory diseases such as …

New insights into vitamin K biology with relevance to cancer

JE Welsh, MJ Bak, CJ Narvaez - Trends in molecular medicine, 2022 - cell.com
Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-
translational γ-carboxylation of a small number of proteins, including clotting factors. These …

The inhibitory roles of vitamin K in progression of vascular calcification

A Shioi, T Morioka, T Shoji, M Emoto - Nutrients, 2020 - mdpi.com
Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-
dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD) …

[HTML][HTML] Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants

H Chen, J Chen, F Zhang, Y Li, R Wang… - Frontiers in …, 2022 - frontiersin.org
Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown
to have antiatherosclerotic and lipid-lowering effects. However, data on human clinical …

Controlled delivery of curcumin and vitamin K2 from hydroxyapatite-coated titanium implant for enhanced in vitro chemoprevention, osteogenesis, and in vivo …

N Sarkar, S Bose - ACS applied materials & interfaces, 2020 - ACS Publications
Successful repair of critical-sized tumor-resection defects, especially in load-bearing bones,
still remains a major challenge in clinical orthopedics. Titanium (Ti) implants have been …

The biological responses of vitamin K2: A comprehensive review

Q Yan, T Zhang, C O'Connor, JW Barlow… - Food Science & …, 2023 - Wiley Online Library
Abstract Vitamin K1 (VitK1) and Vitamin K2 (VitK2), two important naturally occurring
micronutrients in the VitK family, found, respectively, in green leafy plants and algae (VitK1) …