The epigenetic basis of cellular heterogeneity
Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …
substantial heterogeneity in expression levels among morphologically indistinguishable …
[HTML][HTML] Heterogeneity of mesenchymal stem cells in cartilage regeneration: from characterization to application
Articular cartilage is susceptible to damage but hard to self-repair due to its avascular
nature. Traditional treatment methods are not able to produce satisfactory effects …
nature. Traditional treatment methods are not able to produce satisfactory effects …
CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data
C Hu, T Li, Y Xu, X Zhang, F Li, J Bai… - Nucleic Acids …, 2023 - academic.oup.com
Abstract CellMarker 2.0 (http://bio-bigdata. hrbmu. edu. cn/CellMarker or http://117.50.
127.228/CellMarker/) is an updated database that provides a manually curated collection of …
127.228/CellMarker/) is an updated database that provides a manually curated collection of …
Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing
M Zhang, S Hu, M Min, Y Ni, Z Lu, X Sun, J Wu, B Liu… - Gut, 2021 - gut.bmj.com
Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas …
treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas …
[HTML][HTML] Understanding tumor ecosystems by single-cell sequencing: promises and limitations
Cellular heterogeneity within and across tumors has been a major obstacle in
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …
understanding and treating cancer, and the complex heterogeneity is masked if bulk tumor …
Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq
Conventional gene expression studies analyze multiple cells simultaneously or single cells,
for which the exact in vivo or in situ position is unknown. Although cellular heterogeneity can …
for which the exact in vivo or in situ position is unknown. Although cellular heterogeneity can …
Computational methods for trajectory inference from single‐cell transcriptomics
Recent developments in single‐cell transcriptomics have opened new opportunities for
studying dynamic processes in immunology in a high throughput and unbiased manner …
studying dynamic processes in immunology in a high throughput and unbiased manner …
Recent advances in the use of microfluidic technologies for single cell analysis
The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …
as analytical techniques have improved over the past decades. With the advent of …
[HTML][HTML] Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes
C Gu, S Liu, Q Wu, L Zhang, F Guo - Cell research, 2019 - nature.com
Oocyte growth is a key step in forming mature eggs that are ready to be fertilized. The states
and modifications of chromatin represent critical sources of information for this process …
and modifications of chromatin represent critical sources of information for this process …
[HTML][HTML] Tumour heterogeneity: the key advantages of single-cell analysis
M Tellez-Gabriel, B Ory, F Lamoureux… - International journal of …, 2016 - mdpi.com
Tumour heterogeneity refers to the fact that different tumour cells can show distinct
morphological and phenotypic profiles, including cellular morphology, gene expression …
morphological and phenotypic profiles, including cellular morphology, gene expression …