Tumour heterogeneity refers to the fact that different tumour cells can show distinct
morphological and phenotypic profiles, including cellular morphology, gene expression …

Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their
heterogeneity limits their further applications. To identify MSC subpopulations and clarify …

From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

The development of next generation sequencing (NGS) platform-based single-cell RNA
sequencing (scRNA-seq) techniques has tremendously changed biological researches …

Studies on the etiopathogenesis of keloids mostly have focused on fibroblasts and their
dysfunction. In this study, two cutting-edge technologies, single-cell RNA sequencing and …

The cellular heterogeneity of breast cancers still represents a major therapeutic challenge.
The latest genomic studies have classified breast cancers in distinct clusters to inform the …

As the importance of cell heterogeneity has begun to be emphasized, single-cell
sequencing approaches are rapidly adopted to study cell heterogeneity and cellular …

Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs), which is a
highly heterogeneous process. Here we report the cell fate continuum during somatic cell …

Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Recent advances in RNA sequencing enable the generation of genome-wide expression
data at the single-cell level, opening up new avenues for transcriptomics and systems …