The anterior surface of the eye functions as a barrier to the external environment and
protects the delicate underlying tissues from injury. Central to this protection are the corneal …

Purpose Chemotherapy combined with radiation therapy is the most commonly used
approach for treating locally advanced pancreatic cancer. The use of curative doses of …

Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem
cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other …

Despite significant advances in parallel single-cell RNA sequencing revealing astonishing
cellular heterogeneity in many tissue types, the spatial information in the tissue context …

Abstract Background Mesenchymal stromal cells (MSCs) have attracted great attention in
the application of cell-based therapy because of their pluripotent differentiation and …

The intestinal epithelium is responsible for food digestion and nutrient absorption and plays
a critical role in hormone secretion, microorganism defense, and immune response. These …

Alternative polyadenylation (APA) has been discovered to play regulatory roles in the
development of many cancer cells through preferential addition of a poly (A) tail at specific …

Single-cell sequencing (SCS) technology is changing our understanding of cellular
components, functions, and interactions across organisms, because of its inherent …

Human pluripotent stem cells (hPSCs) have promising therapeutic applications due to their
infinite capacity for self-renewal and pluripotency. Genomic stability is imperative for the …

Epigenetic regulation plays crucial roles in the development and disease processes. Since
different cell types with distinct epigenetic characteristics are always intermingled together in …