Simple Summary This study presents the first comprehensive single-cell transcriptomic
characterization at E16 in Ujumqin sheep and Hulunbuir short-tailed sheep (the day of …

A single cell creates surprising heterogeneity in a multicellular organism. While every
organismal cell shares almost an identical genome, molecular interactions in cells alter the …

The organoid field has been developing rapidly during the last decade. Organoids for
human pre-, peri-and post-implantation development have opened an avenue to study these …

The development of next-generation sequencing (NGS) has dramatically increased the
speed and volume of genetic analysis. Furthermore, the range of applications of NGS is …

Highlights•Fully defined and xeno-free culture components have been developed.•Synthetic
2D substrates have achieved high expansion rates.•Improved long-term passage on 2D or …

Medicinal plants are renowned for their abundant production of secondary metabolites,
which exhibit notable pharmacological activities and great potential for drug development …

Gene expression in metazoans is delicately organized. As genetic information transmits from
DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to …

Although innovative technologies for somatic cell reprogramming and transdifferentiation
provide new strategies for the research of translational medicine, including disease …

In humans, zinc finger protein 671 (ZNF671) is a type of transcription factor. However, the
contribution of tumor heterogeneity to the functional role of ZNF671 remains unknown. The …

Intricacy in treatment and diagnosis of breast cancer has been an obstacle due to genotype
and phenotype heterogeneity. Understanding of non-genetic heterogeneity mechanisms …