[HTML][HTML] Antigenic evolution of SARS coronavirus 2
AZ Mykytyn, RAM Fouchier, BL Haagmans - Current Opinion in Virology, 2023 - Elsevier
SARS coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, emerged in China in
December 2019. Vaccines developed were very effective initially, however, the virus has …
December 2019. Vaccines developed were very effective initially, however, the virus has …
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
Abstract In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified,
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that …
Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ. 1.1 variant
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These
variants convergently acquired amino acid substitutions at critical residues in the spike …
variants convergently acquired amino acid substitutions at critical residues in the spike …
Antibody evasion associated with the RBD significant mutations in several emerging SARS-CoV-2 variants and its subvariants
Since the origin of the wild strain of SARS-CoV-2, several variants have emerged, which
were designated as VOC, VOI, and VUM from time to time. The Omicron variant is noted as …
were designated as VOC, VOI, and VUM from time to time. The Omicron variant is noted as …
SARS-CoV-2 BA. 2.86 enters lung cells and evades neutralizing antibodies with high efficiency
L Zhang, A Kempf, I Nehlmeier, A Cossmann, A Richter… - Cell, 2024 - cell.com
Summary BA. 2.86, a recently identified descendant of the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sublineage, contains∼ 35 mutations …
syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sublineage, contains∼ 35 mutations …
Rapid escape of new SARS-CoV-2 Omicron variants from BA. 2-directed antibody responses
Summary In November 2021, Omicron BA. 1, containing a raft of new spike mutations,
emerged and quickly spread globally. Intense selection pressure to escape the antibody …
emerged and quickly spread globally. Intense selection pressure to escape the antibody …
[HTML][HTML] Reversal of the unique Q493R mutation increases the affinity of Omicron S1-RBD for ACE2
Abstract The SARS-CoV-2 Omicron variant containing 15 mutations, including the unique
Q493R, in the spike protein receptor binding domain (S1-RBD) is highly infectious. While …
Q493R, in the spike protein receptor binding domain (S1-RBD) is highly infectious. While …
Spike Protein Mutation-Induced Changes in the Kinetic and Thermodynamic Behavior of Its Receptor Binding Domains Explain Their Higher Propensity to Attain Open …
Spike (S) protein opening in SARS-CoV-2 controls the accessibility of its receptor binding
domains (RBDs) to host receptors and immune recognition. Along the evolution of SARS …
domains (RBDs) to host receptors and immune recognition. Along the evolution of SARS …
Balancing functional tradeoffs between protein stability and ACE2 binding in the SARS-CoV-2 omicron BA. 2, BA. 2.75 and XBB lineages: dynamics-based network …
G Verkhivker, M Alshahrani, G Gupta - Viruses, 2023 - mdpi.com
Evolutionary and functional studies suggested that the emergence of the Omicron variants
can be determined by multiple fitness trade-offs including the immune escape, binding …
can be determined by multiple fitness trade-offs including the immune escape, binding …
Markov State Models and Perturbation-Based Approaches Reveal Distinct Dynamic Signatures and Hidden Allosteric Pockets in the Emerging SARS-Cov-2 Spike …
The new generation of SARS-CoV-2 Omicron variants displayed a significant growth
advantage and increased viral fitness by acquiring convergent mutations, suggesting that …
advantage and increased viral fitness by acquiring convergent mutations, suggesting that …