Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Biomolecules are in constant motion. To understand how they function, and why
malfunctions can cause disease, it is necessary to describe their three-dimensional …

The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key
physiological processes and thus have long been attractive drug targets. With the crystal …

G-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a
ligand-specific manner. The full range of functionally relevant GPCR conformations is poorly …

Proteins are inherently flexible at ambient temperature. At equilibrium, they are
characterized by a set of conformations that undergo continuous exchange within a …

NMR spectroscopy is a powerful tool for biologists interested in the structure, dynamics, and
interactions of biological macromolecules. This review aims at presenting in an accessible …

Abstract µ-Opioid receptors (µORs) are G-protein-coupled receptors that are activated by a
structurally diverse spectrum of natural and synthetic agonists including endogenous …

Protein-folding intermediates have been implicated in amyloid fibril formation involved in
neurodegenerative disorders. However, the structural mechanisms by which intermediates …

Magic-angle spinning solid-state NMR spectroscopy is an important technique to study
molecular structure, dynamics and interactions, and is rapidly gaining importance in …