The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …

Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are
amongst the most prescribed medications worldwide. Most statins work as a competitive …

Intracellular concentrations of drugs and metabolites are often important determinants of
efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many …

Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and
development and drug-induced liver injury (DILI) is a leading cause of preclinical and …

Annually, about 8000 heart and lung transplantations are successfully performed worldwide.
However, morbidity and mortality still pose a major concern. Renal failure in heart and lung …

Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …

In the present study, an open-label, three-treatment, three-period clinical study of
rosuvastatin (RSV) and rifampicin (RIF) when administered alone and in combination was …

In recent years, an increasing number of clinical drug–drug interactions (DDIs) have been
attributed to inhibition of intestinal organic anion-transporting polypeptides (OATPs); …