Luteolin and naringenin are flavonoids found in various foods/beverages and present in
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …

This review provides a practical clinical perspective on the relevance of hepatic transporters
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …

Generating accurate in vitro intrinsic clearance data is an important aspect of predicting in
vivo human clearance. Primary hepatocytes in suspension are routinely used to predict in …

Severe drug-induced liver injury (DILI) remains a major safety issue due to its frequency of
occurrence, idiosyncratic nature, poor prognosis, and diverse underlying mechanisms …

OATP1B1 (SLCO1B1) is predominantly expressed at the basolateral membrane of
hepatocytes and is critically important for the hepatic uptake and clearance of numerous …

Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …

Inhibition of organic anion-transporting polypeptide (OATP) 1B function can lead to serious
clinical drug-drug interactions, thus a thorough evaluation of the potential for this type of …

The review presents metabolic properties of Ivermectin (IVM) as substrate and inhibitor of
human P450 (P450, CYP) enzymes and drug transporters. IVM is metabolized, both in vivo …

Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 are drug transporters
mediating the active hepatic uptake of their substrates. Because they exhibit overlapping …

Differences in the expression and function of the organic anion transporting polypeptide
(OATP) transporters contribute to interindividual variability in atorvastatin clearance …