Seven classes of antiviral agents
A Ianevski, S Ahmad, K Anunnitipat… - Cellular and Molecular …, 2022 - Springer
The viral epidemics and pandemics have stimulated the development of known and the
discovery of novel antiviral agents. About a hundred mono-and combination antiviral drugs …
discovery of novel antiviral agents. About a hundred mono-and combination antiviral drugs …
Emerging roles of SnoRNAs in the pathogenesis and treatment of autoimmune disorders
SnoRNAs (small non-coding RNAs) have recently gained prominence in autoimmune
diseases, revealing their crucial role in modulating the immune response and contributing to …
diseases, revealing their crucial role in modulating the immune response and contributing to …
Introduction to Epigenetics
Epigenetics is the study of inherited variations in gene expression that do not involve
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
changes to DNA sequences. Over 200 unique cell types in a human adult have a nearly …
[HTML][HTML] Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases
L Lei, W Pan, X Shou, Y Shao, S Ye… - Journal of …, 2024 - ncbi.nlm.nih.gov
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal
strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This …
strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This …
[HTML][HTML] CRISPR-Cas12b enables a highly efficient attack on HIV proviral DNA in T cell cultures
M Fan, Y Bao, B Berkhout, E Herrera-Carrillo - Biomedicine & …, 2023 - Elsevier
Abstract Background The novel endonuclease Cas12b was engineered for targeted
genome editing in mammalian cells and is a promising tool for certain applications because …
genome editing in mammalian cells and is a promising tool for certain applications because …
Bridging autoimmunity and epigenetics: The influence of lncRNA MALAT1
Autoimmune disorders represent a heterogeneous spectrum of conditions defined by an
immune system's atypical reactivity against endogenous constituents. In the complex …
immune system's atypical reactivity against endogenous constituents. In the complex …
HIV epidemiology, prevention, treatment, and implementation strategies for public health
The global HIV response has made tremendous progress but is entering a new phase with
additional challenges. Scientific innovations have led to multiple safe, effective, and durable …
additional challenges. Scientific innovations have led to multiple safe, effective, and durable …
[HTML][HTML] Targeted disruption of the BCR-ABL fusion gene by Cas9/dual-sgRNA inhibits proliferation and induces apoptosis in chronic myeloid leukemia cells: Cas9 …
J Zeng, X Liang, L Duan, F Tan, L Chen… - Acta Biochimica et …, 2024 - ncbi.nlm.nih.gov
The BCR-ABL fusion gene, formed by the fusion of the breakpoint cluster region protein
(BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR …
(BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR …
Application of CRISPR–Cas Technology in Drug Development
S Altaf, F Saleem, HM Ikram, A Iftikhar… - Trends in Plant …, 2024 - Springer
The discovery of clustered regularly interspaced short palindromic repeat (CRISPR)-Cas
technology has transformed the science of genome editing, providing exemplary accuracy …
technology has transformed the science of genome editing, providing exemplary accuracy …
CRISPR and gene editing in HIV therapy: A scoping review
E Tuta-Quintero, CM Ayala, MÁM Ardila… - Gaceta Médica de …, 2023 - saber.ucv.ve
Human immunodeficiency virus (HIV) is nowadays one of the major health problems
worldwide. Several strategies have been explored for the eradication of latent HIV-1 …
worldwide. Several strategies have been explored for the eradication of latent HIV-1 …