Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis

AA Bhat, Y Riadi, M Afzal, P Bansal, H Kaur… - … -Research and Practice, 2024 - Elsevier
Sepsis, a potentially fatal illness caused by an improper host response to infection, remains
a serious problem in the world of healthcare. In recent years, the role of ncRNA has …

[HTML][HTML] Rational design of microRNA-responsive switch for programmable translational control in mammalian cells

H Ning, G Liu, L Li, Q Liu, H Huang, Z Xie - Nature Communications, 2023 - nature.com
Artificial RNA translation modulation usually relies on multiple components, such as RNA
binding proteins (RBPs) or microRNAs (miRNAs) for off-switches and double-inverter …

[HTML][HTML] Bioactive molecules against rheumatoid arthritis by suppressing pyroptosis

Q Zhou, T Li, G Fang, Y Pang, X Wang - Pharmaceuticals, 2023 - mdpi.com
Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death
associated with an inflammatory response. Pyroptosis, which occurs in synovial and …

Gasdermin‐B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer

D Sarrio, S Colomo, G Moreno‐Bueno - The FEBS Journal, 2023 - Wiley Online Library
One of the hottest topics in biomedical research is to decipher the functional implications of
the Gasdermin (GSDM) protein family in human pathologies. These proteins are the key …

[HTML][HTML] Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

EA Jalink, AW Schonk, RA Boon… - Frontiers in cardiovascular …, 2024 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in
cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still …

[HTML][HTML] Caspase-5: Structure, Pro-Inflammatory Activity and Evolution

L Eckhart, H Fischer - Biomolecules, 2024 - mdpi.com
Caspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS),
a component of the cell envelope of Gram-negative bacteria. The expression level of the …

[HTML][HTML] Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy

C Springer, D Humayun, R Skouta - Cancers, 2024 - mdpi.com
Simple Summary Cuproptosis is a recently identified form of cell death induced by
imbalanced copper levels. We aimed to explore the mechanism underlying copper-induced …

[HTML][HTML] Gasdermin D-Mediated Pyroptosis in Diabetic Cardiomyopathy: Molecular Mechanisms and Pharmacological Implications

Z Liu, Y Chen, Y Mei, M Yan, H Liang - Molecules, 2023 - mdpi.com
Diabetic cardiomyopathy (DCM) is a pathophysiological condition triggered by diabetes
mellitus (DM), which can lead to heart failure (HF). One of the most important cellular …

[HTML][HTML] Human coronavirus 229E infection inactivates pyroptosis executioner gasdermin D but ultimately leads to lytic cell death partly mediated by gasdermin E

X Martiañez-Vendrell, J Bloeme-ter Horst… - Viruses, 2024 - mdpi.com
Human coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections
and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell …

Discovery of N-Substituted Acetamide Derivatives as Promising P2Y14R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay

W Liu, S Mao, Y Wang, M Wang, M Li… - Journal of Medicinal …, 2024 - ACS Publications
P2Y14 receptor (P2Y14R) is activated by uridine 5′-diphosphate-glucose, which is
involved in many human inflammatory diseases. Based on the molecular docking analysis of …