[HTML][HTML] Targeting protein-protein interaction interfaces in COVID-19 drug discovery

C Chang, SM Lin, R Satange, SC Lin, SC Sun… - Computational and …, 2021 - Elsevier
To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another
50 million individuals and wreaked havoc on the global economy. The crisis has spurred the …

Current status and future perspectives of computational studies on human–virus protein–protein interactions

X Lian, X Yang, S Yang, Z Zhang - Briefings in Bioinformatics, 2021 - academic.oup.com
The protein–protein interactions (PPIs) between human and viruses mediate viral infection
and host immunity processes. Therefore, the study of human–virus PPIs can help us …

Microbiota and cancer: current understanding and mechanistic implications

AA Khan, AT Sirsat, H Singh, P Cash - Clinical and Translational Oncology, 2022 - Springer
During last few decades, role of microbiota and its importance in several diseases has been
a hot topic for research. The microbiota is considered as an accessory organ for maintaining …

Pathways of coagulopathy and inflammatory response in SARS-CoV-2 infection among type 2 diabetic patients

OZ Akácsos-Szász, S Pál, KI Nyulas… - International Journal of …, 2023 - mdpi.com
Chronic inflammation and endothelium dysfunction are present in diabetic patients. COVID-
19 has a high mortality rate in association with diabetes, partially due to the development of …

Comparative Host–Pathogen Interaction Analyses of SARS-CoV2 and Aspergillus fumigatus, and Pathogenesis of COVID-19-Associated Aspergillosis

AA Khan, F Farooq, SK Jain, P Golinska, M Rai - Microbial ecology, 2021 - Springer
COVID-19 caused a global catastrophe with a large number of cases making it one of the
major pandemics of the human history. The clinical presentations of the disease are …

[HTML][HTML] Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19

AA Khan, HO Singh, M Bilal… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Rapid infectivity of SARS-CoV2 with recent viral variants is posing a challenge in the
development of robust therapeutic strategies. On the other hand, microbiota is debated for its …

Drug repositioning via host-pathogen protein-protein interactions for the treatment of cervical cancer

M Kori, B Turanli, KY Arga - Frontiers in oncology, 2023 - frontiersin.org
Introduction Integrating interaction data with biological knowledge can be a critical approach
for drug development or drug repurposing. In this context, host-pathogen-protein-protein …

PLM-GAN: A Large-Scale Protein Loop Modeling Using pix2pix GAN

MNA Khalaf, THA Soliman, SS Mohamed - ACS omega, 2023 - ACS Publications
Revealing the tertiary structure of proteins holds huge significance as it unveils their vital
properties and functions. These intricate three-dimensional configurations comprise diverse …

[HTML][HTML] Exploring SARS-CoV2 host-pathogen interactions and associated fungal infections cross-talk: Screening of targets and understanding pathogenesis

AA Khan, SK Jain, M Rai, S Panda - Computational and Structural …, 2022 - Elsevier
The COVID-19 associated opportunistic fungal infections have posed major challenges in
recent times. Global scientific efforts have identified several SARS-CoV2 host-pathogen …

A Pan-Cancer In Silico Analysis of the COVID-19 Internalization Protease: Transmembrane Proteaseserine-2

Y Meng, J Sun, G Zhang, T Yu, H Piao - Frontiers in Genetics, 2022 - frontiersin.org
The new coronavirus (2019-nCoV) is an emerging pathogen that can cause severe
respiratory infections in humans. It is worth noting that many of the affected COVID-19 …