Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and
cardiovascular disease. Recently, one particular lipid class has been shown to influence the …

Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian
rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of …

Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

Oversupply of fatty acids (FAs) to cardiomyocytes (CMs) is associated with increased
ceramide content and elevated the risk of lipotoxic cardiomyopathy. Here we investigate the …

Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been
proposed to regulate cellular processes by influencing membrane properties and by directly …

The endoplasmic reticulum (ER) plays a key role in the regulation of protein folding, lipid
synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis …

Reduced feed intake in early lactation prompts increased fat mobilization to meet dairy cow
energy needs for milk production. The increased lipolysis in cows presents significant health …

Cardiolipin (CL) is a unique tetra-acyl phospholipid localized to the inner mitochondrial
membrane and essential for normal respiratory function. It has been previously reported that …