Deciphering the polygenic basis of racial disparities in prostate cancer by an integrative analysis of genomic and Transcriptomic Data
W Zhang, T Nicholson, K Zhang - Cancer Prevention Research, 2022 - AACR
Prostate cancer prevalence in African Americans (AA) is over 1.5 times the prevalence in
European Americans (EA). Among over a hundred index risk SNPs for prostate cancer, only …
European Americans (EA). Among over a hundred index risk SNPs for prostate cancer, only …
MicroRNAs differentially expressed in prostate cancer of African-American and European-American men
E Amankwah - Cancer Translational Medicine, 2018 - search.proquest.com
African-American (AA) men have higher rates of prostate cancer incidence and mortality
compared with European-American (EA) men. Although several socioeconomic and …
compared with European-American (EA) men. Although several socioeconomic and …
[图书][B] Integrative statistical methods to understand the genetic basis of complex traits
G Kichaev - 2018 - search.proquest.com
Abstract The Genome-wide Association study (GWAS) is one of the primary tools for
understanding the genetic basis of complex traits. In this dissertation I introduce enhanced …
understanding the genetic basis of complex traits. In this dissertation I introduce enhanced …
[PDF][PDF] Machine learning and large scale cancer omic data: decoding the biological mechanisms underpinning cancer
V Fanfani - 2022 - core.ac.uk
Many of the mechanisms underpinning cancer risk and tumorigenesis are still not fully
understood. However, the next-generation sequencing revolution and the rapid advances in …
understood. However, the next-generation sequencing revolution and the rapid advances in …
Validation of prostate cancer risk variants by CRISPR/Cas9 mediated genome editing
GWAS have identified numerous SNPs associated with prostate cancer risk. One such SNP
is rs10993994. It is located in the MSMB promoter, associates with MSMB encoded β …
is rs10993994. It is located in the MSMB promoter, associates with MSMB encoded β …
Functional Characterization of Genetic Variation with in silico Predictions of Cell-Type-Specific Regulatory Elements
T Amariuta - 2020 - search.proquest.com
Genome-wide association studies (GWAS) have implicated thousands of complex trait-
variant associations, an estimated 90% of which reside in the noncoding genome. While …
variant associations, an estimated 90% of which reside in the noncoding genome. While …
[PDF][PDF] Identification of novel susceptibility loci and genes for prostate cancer risk: A 1 transcriptome-wide association study in over 140,000 European descendants 2
A Eeles, W Zheng - researchgate.net
Genome-wide association study identified prostate cancer risk variants explain only a
relatively 72 small fraction of its familial relative risk, and the genes responsible for many of …
relatively 72 small fraction of its familial relative risk, and the genes responsible for many of …
[HTML][HTML] Treatment of prostate cancer in men with a somatic or BRCA germline mutation
N Mehra - Tijdschrift voor Urologie, 2020 - Springer
Er zijn nieuwe inzichten in een subgroep van prostaatkankerpatiënten met veranderingen in
de breast cancer susceptibility genes BRCA1/2. BRCA1/2 zijn eiwitten met een belangrijke …
de breast cancer susceptibility genes BRCA1/2. BRCA1/2 zijn eiwitten met een belangrijke …
[PDF][PDF] Behandeling van prostaatkanker bij mannen met een somatische of BRCA-kiembaanmutatie
N Mehra - Tijdschrift voor Urologie, 2020 - academia.edu
Er zijn nieuwe inzichten in een subgroep van prostaatkankerpatiënten met veranderingen in
de breast cancer susceptibility genes BRCA1/2. BRCA1/2 zijn eiwitten met een belangrijke …
de breast cancer susceptibility genes BRCA1/2. BRCA1/2 zijn eiwitten met een belangrijke …
[图书][B] Computational methods to discern the genetic basis of complex disease
M Roytman - 2018 - search.proquest.com
Genome-wide association studies (GWAS) have identified thousands of regions in the
genome containing risk variants for complex traits. Due to the correlation structure between …
genome containing risk variants for complex traits. Due to the correlation structure between …