Targeted therapies for triple-negative breast cancer: combating a stubborn disease
Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …
cancers that have a poor clinical outcome. Although no approved targeted therapy is …
Interactome3D: adding structural details to protein networks
Network-centered approaches are increasingly used to understand the fundamentals of
biology. However, the molecular details contained in the interaction networks, often …
biology. However, the molecular details contained in the interaction networks, often …
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are
thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a …
thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a …
Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development
L Imamovic, MOA Sommer - Science translational medicine, 2013 - science.org
New drug deployment strategies are imperative to address the problem of drug resistance,
which is limiting the management of infectious diseases and cancers. We evolved resistance …
which is limiting the management of infectious diseases and cancers. We evolved resistance …
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with
high mortality. We used a systematic drug repositioning bioinformatics approach querying a …
high mortality. We used a systematic drug repositioning bioinformatics approach querying a …
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies
Inhibitors targeting KRASG12C, a mutant form of the guanosine triphosphatase (GTPase)
KRAS, are a promising new class of oncogene-specific therapeutics for the treatment of …
KRAS, are a promising new class of oncogene-specific therapeutics for the treatment of …
Co-delivery of drugs and plasmid DNA for cancer therapy
PY Teo, W Cheng, JL Hedrick, YY Yang - Advanced drug delivery reviews, 2016 - Elsevier
Cancer is an extremely complex disease involving multiple signaling pathways that enable
tumor cells to evade programmed cell death, thus making cancer treatment extremely …
tumor cells to evade programmed cell death, thus making cancer treatment extremely …
Applying synthetic lethality for the selective targeting of cancer
DP McLornan, A List, GJ Mufti - New England Journal of Medicine, 2014 - Mass Medical Soc
Applying Synthetic Lethality for the Selective Targeting of Cancer | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Oxidative stress in apoptosis and cancer: an update
The oxygen paradox tells us that oxygen is both necessary for aerobic life and toxic to all life
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …
forms. Reactive oxygen species (ROS) touch every biological and medical discipline …
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
Understanding the emerging models of adaptive resistance is key to overcoming cancer
chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo …
chemotherapy failure. Using human breast cancer explants, in vitro cell lines, mouse in vivo …