3-Chymotrypsin-like Protease (3CLpro) of SARS-CoV-2: Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and …

VMF Amorim, EP Soares, ASA Ferrari, DGS Merighi… - Viruses, 2024 - mdpi.com
Proteases represent common targets in combating infectious diseases, including COVID-19.
The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19 …

Preclinical discovery and development of nirmatrelvir/ritonavir combinational therapy for the treatment of COVID-19 and the lessons learned from SARS-COV-2 …

P Pagliano, A Spera, C Sellitto, G Scarpati… - Expert Opinion on …, 2023 - Taylor & Francis
ABSTRACT Introduction Nirmatrelvir/ritonavir (Paxlovid®) represent an oral antiviral therapy
approved for the treatment of COVID-19. Extensive in vitro and in vivo studies have reported …

[HTML][HTML] How do we best use Paxlovid and other covid antivirals?

K Lang - bmj, 2023 - bmj.com
How do we best use Paxlovid and other covid antivirals? | The BMJ Skip to main content
Intended for healthcare professionals Access provided by Google Indexer Subscribe My …

[HTML][HTML] Pharmacological targeting of the hyper-inflammatory response to SARS-CoV-2-infected K18-hACE2 mice using a cluster of differentiation 36 receptor …

J Gauvin, DN Huynh, I Dubuc, C Lê… - Frontiers in …, 2024 - frontiersin.org
The scientific and medical community faced an unprecedented global health hazard that led
to nearly 7 million deaths attributable to the rapid spread of severe acute respiratory …

[PDF][PDF] Efficacy and safety of casirivimab-imdevimab combination on COVID-19 patients: A systematic review and meta-analysis randomized controlled trial

IA Wicaksono, C Suhandi, KM Elamin, N Wathoni - Heliyon, 2023 - cell.com
Background The advantages and disadvantages of casirivimab-imdevimab for coronavirus
disease 2019 are not well understood. We conducted a systematic review and meta …

Population Pharmacokinetics of Nirmatrelvir in Chinese Patients with COVID-19: Therapeutic Drug Monitoring and Dosing Regimen Selection in Clinical Practice

P Yang, W Liu, Y Ying, L Zhao, X Xiong, X Zhang… - International Journal of …, 2024 - Elsevier
ABSTRACT OBJECTIVES To establish a population pharmacokinetics (PopPK) model of
nirmatrelvir in Chinese COVID-19 patients and provide reference for refining the dosing …

[HTML][HTML] COVID-19 Associated Cardiovascular Disease—Risks, Prevention and Management: Heart at Risk Due to COVID-19

A Kemerley, A Gupta, M Thirunavukkarasu… - Current Issues in …, 2024 - mdpi.com
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the
resulting COVID-19 pandemic have had devastating and lasting impact on the global …

[PDF][PDF] Фавипиравир как средство терапии COVID-19

КВ Балакин, РВ Стороженко… - Научный бюллетень …, 2023 - chemrar.ru
Фавипиравир, разработанный японскими исследователями в качестве средства
терапии гриппа и других РНК-вирусных инфекций, в 2020-2022 годах стал массово …

Modelling long COVID using Bayesian networks

G Perez Chacon, S Mascaro, MJ Estcourt… - medRxiv, 2024 - medrxiv.org
Motivated by the ambiguity of operational case definitions for long COVID and the impact of
the lack of a common causal language on long COVID research, in early 2023 we began …

[PDF][PDF] Молекулярно-эпидемиологический мониторинг и оценка эффективности средств специфической диагностики и вакцинопрофилактики новой …

ВА Гущин - 2023 - gamaleya.org
Актуальность исследования. В последние десятилетия эпидемические вспышки и
пандемии, вызываемыми возбудителями вновь появляющихся инфекционных …