A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for
maintenance of the species. However, the developmental trajectories and heterogeneity of …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a
haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Development of testes in the mammalian embryo requires the formation and assembly of
several cell types that allow these organs to achieve their roles in male reproduction and …

Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY,
is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility …

The mammalian Y chromosome acts as a dominant male determinant as a result of the
action of a single gene, Sry, whose role in sex determination is to initiate testis rather than …

In mammals, the transcription factor SRY, encoded by the Y chromosome, is normally
responsible for triggering the indifferent gonads to develop as testes rather than ovaries …