Essential fatty acids and their metabolites in the pathobiology of inflammation and its resolution

UN Das - Biomolecules, 2021 - mdpi.com
Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation.
Prostaglandin E2 (PGE2) and leukotriene B4/D4/E4 (LTB4/LD4/LTE4), derived from AA, are …

Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity

M Saichi, MZ Ladjemi, S Korniotis, C Rousseau… - Nature Cell …, 2021 - nature.com
COVID-19 can lead to life-threatening respiratory failure, with increased inflammatory
mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high …

Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19

R Sparks, WW Lau, C Liu, KL Han, KL Vrindten, G Sun… - Nature, 2023 - nature.com
Acute viral infections can have durable functional impacts on the immune system long after
recovery, but how they affect homeostatic immune states and responses to future …

[HTML][HTML] The immunology of SARS-CoV-2 infections and vaccines

L Grigoryan, B Pulendran - Seminars in immunology, 2020 - Elsevier
Abstract SARS-CoV-2, the virus that causes COVID-19, emerged in late 2019, and was
declared a global pandemic on March 11th 2020. With over 50 million cases and 1.2 million …

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

S Gee, M Chandiramani, J Seow, E Pollock… - Nature …, 2021 - nature.com
Despite extensive studies into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the effect of maternal infection on the neonate is unclear. To investigate this, we …

T cell immunobiology and cytokine storm of COVID‐19

XH Luo, Y Zhu, J Mao, RC Du - Scandinavian journal of …, 2021 - Wiley Online Library
Abstract 2019 coronavirus disease (COVID‐19) presents as a newly recognized pneumonia
and could rapidly progress into acute respiratory distress syndrome which has brought …

COVID-19 pneumonia and the appropriate use of antibiotics

AS Ginsburg, KP Klugman - The Lancet Global Health, 2020 - thelancet.com
Talking about COVID-19 has become a ritual for everyone. The COVID-19 pandemic has put
respiratory illness—infection, pneumonia, and death—in the daily headlines. Many of us …

Calcifediol treatment and hospital mortality due to COVID-19: a cohort study

JF Alcala-Diaz, L Limia-Perez, R Gomez-Huelgas… - Nutrients, 2021 - mdpi.com
Context. Calcifediol has been proposed as a potential treatment for COVID-19 patients.
Objective: To compare the administration or not of oral calcifediol on mortality risk of patients …

T cell immunity to SARS-CoV-2 following natural infection and vaccination

AT DiPiazza, BS Graham, TJ Ruckwardt - Biochemical and biophysical …, 2021 - Elsevier
SARS-CoV-2 first emerged in the human population in late 2019 in Wuhan, China, and in a
matter of months, spread across the globe resulting in the Coronavirus Disease 19 (COVID …

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

A Pérez-Gómez, J Vitallé, C Gasca-Capote… - Cellular & Molecular …, 2021 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces
an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) …