Semaglutide in patients with obesity-related heart failure and type 2 diabetes

MN Kosiborod, MC Petrie, BA Borlaug… - … England Journal of …, 2024 - Mass Medical Soc
Background Obesity and type 2 diabetes are prevalent in patients with heart failure with
preserved ejection fraction and are characterized by a high symptom burden. No approved …

Mitral regurgitation in heart failure with preserved ejection fraction: The interplay of valve, ventricle, and atrium

S Dhont, G van den Acker, T van Loon… - European journal of …, 2024 - Wiley Online Library
Mitral regurgitation (MR) is highly prevalent among patients with heart failure and preserved
ejection fraction (HFpEF). Despite this combination being closely associated with …

SGLT2 inhibitors as a potential therapeutic option for pulmonary hypertension: mechanisms and clinical perspectives

JS Tan, Y Wei, L Chong, Y Yang, S Hu… - Critical Reviews in …, 2024 - Taylor & Francis
Pulmonary arterial hypertension (PAH), one subtype of pulmonary hypertension (PH), is a
life-threatening condition characterized by pulmonary arterial remodeling, elevated …

[HTML][HTML] Semaglutide and NT-proBNP in Obesity-Related HFpEF: Insights From the STEP-HFpEF Program

MC Petrie, BA Borlaug, J Butler, MJ Davies… - Journal of the American …, 2024 - Elsevier
Background The glucagon-like peptide-1 receptor agonist, semaglutide, improved health
status and reduced body weight in patients with obesity-related heart failure (HF) with …

Epidemiology and Management of Patients With Kidney Disease and Heart Failure With Preserved Ejection Fraction

ML Tuttle, JC Fang, MJ Sarnak, W McCallum - Seminars in Nephrology, 2024 - Elsevier
Heart failure with preserved ejection fraction (HFpEF) comprises approximately one-half of
all diagnoses of heart failure. There is significant overlap of this clinical syndrome with …

Management of Pulmonary Hypertension in the Context of Heart Failure with Preserved Ejection Fraction

E Kozaily, ER Akdogan, NS Dorsey… - Current hypertension …, 2024 - Springer
Abstract Purpose of Review To review the current evidence and modalities for treating
pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) …

Invasive Hemodynamic Changes Associated With Sodium‐Glucose Cotransporter‐2 Inhibitors: A Systematic Review and Meta‐Analysis of Randomized Controlled …

A Idowu, O Adebolu, C Bruce, B Nriagu… - Cardiovascular …, 2024 - Wiley Online Library
Sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) have been shown to lower incident
heart failure (HF) and HF hospitalizations, but the mechanisms of benefit in relation to …

Role of splanchnic circulation in the pathogenesis of heart failure: State-of-the-art review

H Yaku, M Fudim, SJ Shah - Journal of Cardiology, 2024 - Elsevier
A hallmark of heart failure (HF), whether it presents itself during rest or periods of physical
exertion, is the excessive elevation of intracardiac filling pressures at rest or with exercise …

Screening for Unrecognized HFpEF in Atrial Fibrillation and for Unrecognized Atrial Fibrillation in HFpEF

YNV Reddy, P Noseworthy, BA Borlaug, NM Albert - Heart Failure, 2024 - jacc.org
Because of the bidirectional relationship between atrial fibrillation (AF) and heart failure with
preserved ejection fraction (HFpEF), individuals with either condition require consideration …

[HTML][HTML] Rest and exercise-stress estimated pulmonary capillary wedge pressure using real-time free-breathing cardiovascular magnetic resonance imaging

SJ Backhaus, A Schulz, T Lange, R Evertz… - Journal of …, 2024 - Elsevier
Background Identification of increased pulmonary capillary wedge pressure (PCWP) by right
heart catheterisation (RHC) is the reference standard for the diagnosis of heart failure with …