Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …

The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and
development in bladder cancer. However, the underlying molecular mechanisms remain …

While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last
decade, the focus regarding their mechanisms of action has been primarily on the RNA …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …

Background Esophageal squamous cell carcinoma (ESCC) is a common invasive
malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding …