[HTML][HTML] T cell responses in patients with COVID-19

Z Chen, E John Wherry - Nature Reviews Immunology, 2020 - nature.com
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to
provide long-term protection from reinfection with SARS-CoV-2, remains debated …

[HTML][HTML] A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

O Sharma, AA Sultan, H Ding, CR Triggle - Frontiers in immunology, 2020 - frontiersin.org
A novel coronavirus, which has been designated as severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and …

[HTML][HTML] Effects of COVID-19 on the nervous system

C Iadecola, J Anrather, H Kamel - Cell, 2020 - cell.com
Neurological complications have emerged as a significant cause of morbidity and mortality
in the ongoing COVID-19 pandemic. Beside respiratory insufficiency, many hospitalized …

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

H Gu, Q Chen, G Yang, L He, H Fan, YQ Deng, Y Wang… - Science, 2020 - science.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the
development of small-animal models for severe acute respiratory syndrome coronavirus 2 …

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

ED Hottz, IG Azevedo-Quintanilha… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen
responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel …

[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19

BJ Meckiff, C Ramírez-Suástegui, V Fajardo, SJ Chee… - Cell, 2020 - cell.com
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity

CR Moderbacher, SI Ramirez, JM Dan, A Grifoni… - Cell, 2020 - cell.com
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …

Individuals with obesity and COVID‐19: a global perspective on the epidemiology and biological relationships

BM Popkin, S Du, WD Green, MA Beck… - Obesity …, 2020 - Wiley Online Library
The linkage of individuals with obesity and COVID‐19 is controversial and lacks systematic
reviews. After a systematic search of the Chinese and English language literature on COVID …

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

D Mathew, JR Giles, AE Baxter, DA Oldridge… - Science, 2020 - science.org
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …