[HTML][HTML] COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

A Bonifacius, S Tischer-Zimmermann, AC Dragon… - Immunity, 2021 - cell.com
Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …

Virus-host interactome and proteomic survey reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

J Li, M Guo, X Tian, X Wang, X Yang, P Wu, C Liu… - Med, 2021 - cell.com
Background The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a global public health …

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses

B Agerer, M Koblischke, V Gudipati… - Science …, 2021 - science.org
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus
control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell …

Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants

C Sun, C Xie, GL Bu, LY Zhong, MS Zeng - Signal Transduction and …, 2022 - nature.com
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

COVID-19 in Africa: Dampening the storm?

M Mbow, B Lell, SP Jochems, B Cisse, S Mboup… - Science, 2020 - science.org
Coronavirus disease 2019 (COVID-19) has spread rapidly and extensively to most countries
in the world, resulting in considerable mortality in Europe and the United States, as well as …

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

L Ma, SK Sahu, M Cano, V Kuppuswamy, J Bajwa… - Science …, 2021 - science.org
Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes …

Immune deficiency is a risk factor for severe COVID‐19 in people living with HIV

C Hoffmann, JL Casado, G Härter, P Vizcarra… - HIV …, 2021 - Wiley Online Library
Objectives A prior T cell depletion induced by HIV infection may carry deleterious
consequences in the current COVID‐19 pandemic. Clinical data on patients co‐infected with …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Coronavirus disease 2019 (COVID‐19): An overview of the immunopathology, serological diagnosis and management

AU Anka, MI Tahir, SD Abubakar… - Scandinavian …, 2021 - Wiley Online Library
SARS‐CoV‐2 is a novel human coronavirus responsible for the Coronavirus disease 2019
(COVID‐19) pandemic. Pneumonia and acute respiratory distress syndrome are the major …