DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

M Thépaut, J Luczkowiak, C Vivès, N Labiod… - PLoS …, 2021 - journals.plos.org
The efficient spread of SARS-CoV-2 resulted in a unique pandemic in modern history.
Despite early identification of ACE2 as the receptor for viral spike protein, much remains to …

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Q Lu, J Liu, S Zhao, MFG Castro, M Laurent-Rolle… - Immunity, 2021 - cell.com
Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) engagement with immune cells, most express little, if any, of the canonical receptor of …

Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses

EA Bordt, LL Shook, C Atyeo, KM Pullen… - Science translational …, 2021 - science.org
There is a persistent bias toward higher prevalence and increased severity of coronavirus
disease 2019 (COVID-19) in males. Underlying mechanisms accounting for this sex …

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

K Keyhanian, RP Umeton, B Mohit, V Davoudi… - Journal of …, 2021 - Elsevier
Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates …

[HTML][HTML] Androgen signaling regulates SARS-CoV-2 receptor levels and is associated with severe COVID-19 symptoms in men

RM Samuel, H Majd, MN Richter, Z Ghazizadeh… - Cell Stem Cell, 2020 - cell.com
SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the
disease and potential treatment options remains limited. The infection occurs through …

[HTML][HTML] Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19

D Scozzi, M Cano, L Ma, D Zhou, JH Zhu… - JCI insight, 2021 - ncbi.nlm.nih.gov
Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids
released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could …

Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals

F Gong, Y Dai, T Zheng, L Cheng… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Marked progress is achieved in understanding the physiopathology of
coronavirus disease 2019 (COVID-19), which caused a global pandemic. However, the …

T-helper cell subset response is a determining factor in COVID-19 progression

FJ Gil-Etayo, P Suàrez-Fernández… - Frontiers in cellular …, 2021 - frontiersin.org
The immune response type organized against viral infection is determinant in the prognosis
of some infections. This work has aimed to study Th polarization in acute COVID-19 and its …

Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice

J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
T-cell immunity is important for recovery from COVID-19 and provides heightened immunity
for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in …