Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

The activation of the N-methyl D-aspartate receptor (NMDAR) is controlled by a glutamate-
binding site and a distinct, independently regulated, co-agonist-binding site. In most brain …

While the dopamine hypothesis has dominated schizophrenia research for several decades,
more recent studies have highlighted the role of fast synaptic transmitters and their receptors …

Over the last 20 years, glutamatergic models of schizophrenia have become increasingly
accepted as etiopathological models of schizophrenia, based on the observation that …

Importance In addition to dopaminergic hyperactivity, hypofunction of theN-methyl-d-
aspartate receptor (NMDAR) has an important role in the pathophysiology of schizophrenia …

Neurotransmitters as electrochemical signaling molecules are essential for proper brain
function and their dysfunction is involved in several mental disorders. Therefore, the …

Methamphetamine (METH) is a frequent drug of abuse in US populations and commonly
associated with psychosis. This may be a factor in frequent criminal justice referrals and …

Severe psychiatric disorders such as schizophrenia are related to cognitive and negative
symptoms, which often are resistant to current treatment approaches. The glutamatergic …

D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of
many preclinical studies to ascertain the nature of its metabolism, its regional and cellular …