Since the identification and characterization of gasdermin (GSDM) D as the main effector of
inflammatory regulated cell death (or pyroptosis), literature on the GSDM family of pore …

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an
attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Neuroinflammation is initiated with an aberrant innate immune response in the central
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …

Despite significant advances in diagnostic techniques and treatment approaches, the
prognosis of pancreatic ductal adenocarcinoma (PDAC) is still poor. Previous studies have …

Sepsis remains one of the most common and lethal conditions globally. Currently, no
proposed target specific to sepsis improves survival in clinical trials. Thus, an in-depth …

Doxorubicin (DOX) is a highly effective and extensively used chemotherapeutic drug but is
limited by its cardiotoxicity. In our previous study, we showed that DOX-induced …

IL‐1β can exit the cytosol as an exosomal cargo following inflammasome activation in
intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)‐dependent manner. The …

Itaconate is produced by an enzyme encoded by the immune-responsive gene 1 (IRG1) and
exerts antibacterial, anti-inflammatory, and antioxidant effects via multiple mechanisms …

Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …