Proteoforms, which arise from post-translational modifications, genetic polymorphisms and
RNA splice variants, play a pivotal role as drivers in biology. Understanding proteoforms is …

Protein–protein interactions (PPIs) are at the heart of the molecular landscape permeating
life. Proteomics studies can explore this protein interaction landscape using mass …

Inside the chase after those elusive proteoforms | Nature Methods Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Working in tandem with kinases via a dynamic interplay of phosphorylation and
dephosphorylation of proteins, phosphatases regulate many cellular processes and thus …

Snakebite envenomation has been a long-standing global issue that is difficult to treat,
largely owing to the flawed nature of current immunoglobulin-based antivenom therapy and …

Introduction Regenerative myogenesis plays a crucial role in mature myofibers to counteract
muscular injury or dysfunction due to neuromuscular disorders. The activation of specialized …

With growing recognition and acknowledgement of the genuine complexity of proteomes, we
are finally entering the post-proteogenomic era. Routine assessment of proteomes as …

Extracellular vesicles (EVs) are anucleate particles enclosed by a lipid bilayer that are
released from cells via exocytosis or direct budding from the plasma membrane. They …

Mass spectrometry‐based approaches to assess protein conformation have become widely
utilized due to their sensitivity, low sample requirements, and broad applicability to proteins …

Tandem mass spectrometry of peptides and proteins generates mass spectra of their gas-
phase fragmentation product ions, including N-terminal, C-terminal, and internal fragment …