Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Background Neuronal pyroptosis and neuroinflammation with excess microglial activation
are widely involved in the early pathological process of ischemic stroke. Repetitive …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

An intense, stereotyped inflammatory response occurs in response to ischaemic and non-
ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein …

Myocardial ischemia-reperfusion injury induces a sterile inflammatory response, leading to
further injury that contributes to the final infarct size. Locally released danger-associated …